Bioactive Small Molecules

A vast array of small, non-peptide, organic compounds that are biologically active. Products include receptor antagonists, molecular probes, metabolites, GPCR ligands, neurotransmitters, ion channel modulators, and signaling activators and inhibitors.

Search Within Results

5,401 – 5,415 of 60,541 results

5,401

Cayman Chemical β-Secretase Inhibitor IV, Purity: ≥98%, CAS: 797035-11-1, 5 mg

An inhibitor of BACE1 and 2 (IC50s = 15 and 230 nM for human BACE1 and 2, respectively); has >500-fold selectivity for BACE1 and 2 over the aspartyl proteases renin and cathepsin D; inhibits secretion of APP (IC50 = 29 nM) in HEK293T cells transfected with a truncated human APP; inhibits formation of the Aβ peptides Aβ38, Aβ40, and Aβ42 in primary chick neurons (IC50s = 3.7, 4.7, and 4.8 nM, respectively)

Pricing & Availability

5,402

TARGETMOL CHEMICALS INC C-021 DIHYDROCHLORIDE 5MG

Also available in 1 mg 10 mg 25 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. C-021 dihydrochloride is a potent CCR4 antagonist. It potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM. purity: 98%

Pricing & Availability

5,403

Cayman Chemical ZLY032, Purity: ≥98%, CAS: 2314465-67-1, 5 mg

A dual agonist of FFAR1/GPR40 (EC50 = 68 nM in a FLIPR assay) and PPARδ (102 nM in a reporter assay); selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 µM for both); reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in the ob/ob mouse model of metabolic disease at 40 mg/kg; reduces hepatic steatosis and plasma ALT and AST levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet at 40 mg/kg

Pricing & Availability

5,404

Cayman Chemical Hecogenin, Purity: ≥80%, CAS: 467-55-0, 1 g

A natural steroid sapogenin with diverse biological activities; decreases fMLP-induced superoxide anion formation by rat neutrophils by 23.6% (10 μM); inhibits PMA-induced MPO release from human neutrophils (1 μg/ml); inhibits the proliferation of at least seven breast cancer cell lines (IC50s = 28.7-38.2 μM); decreases the number of glutamate-induced TUNEL-positive primary rat spinal motor neurons by 11% (1 μM); decreases the mucosal lesion area of ethanol-induced gastric ulceration in mice (15 mg/kg); decreases tumor volume in an MDA-MB-231 human breast cancer mouse xenograft model (10 mg/kg three times per week)

Pricing & Availability

5,405

Cayman Chemical Didecanoin, Purity: ≥98%, CAS: 53988-07-1, 50 mg

A diacylglycerol

Pricing & Availability

5,406

Cayman Chemical 1,2-Dioleoyl-3-Decanoyl-rac-glycerol, Purity: ≥98%, CAS: 88286-47-9, 5 mg

A triacylglycerol; has been found in date seed oil

Pricing & Availability

5,407

Cayman Chemical 1,2,3-Tri-13(Z),16(Z)-Docosadienoyl-glycerol, Purity: ≥98%, CAS: 958760-53-7, 5 mg

A triacylglycerol

Pricing & Availability

5,408

Cayman Chemical A-196, Purity: ≥98%, CAS: 1982372-88-2, 10 mg

A selective inhibitor of SUV420H1 and SUV420H2 (IC50s = 25 and 144 nM, respectively) that inhibits the di- and trimethylation of H4K20me in multiple cell lines

Pricing & Availability

5,409

Cayman Chemical ADTL-EI1712, Purity: ≥98%, CAS: 2414916-45-1, 5 mg

A dual ERK1 and ERK5 inhibitor (IC50s = 40.43 and 64.5 nM, respectively); reduces ERK1 and ERK5 activity by 93.5% and 89.4%, respectively, but also inhibits ERK2 activity by 92.7%, in a panel of 100 kinases at 1 µM; inhibits proliferation of HL-60 and MKN74 cancer cells (IC50s = 1.26 and 2.55 µM, respectively); reduces tumor growth and intratumor phosphorylation of ERK1/2 and ERK5 in an MKN74 mouse xenograft model at 50 mg/kg per day

Pricing & Availability

5,410

Medchemexpress LLC Brd0539 | 1403838-79-8 | MFCD32709969 | 98.3% | 452.54 | 50 MG

BRD0539 is an inhibitor of *Streptococcus pyogenes* Cas9 (SpCas9) with an IC50 of 22 μM in an *in vitro* DNA cleavage assay. It dose-dependently blocks the formation of the DNA-bound state and impairs perturbation induced by 4PAM DNA.

Does not interfere with SpCas9:gRNA interaction
Inhibits SpCas9 in eGFP-disruption assay
Cannot inhibit FnCpf1

Pricing & Availability

5,411

Cayman Chemical 1-β-D-Glucosylsphingadienine, Purity: ≥98%, CAS: 114200-59-8, 5 mg

A sphingolipid

Pricing & Availability

5,412

Cayman Chemical ANTIBODY MCTR3 100ug

A specialized pro-resolving mediator; accelerates tissue regeneration in planaria at a concentration of 1 and 100 nM; reduces neutrophil infiltration, shortens inflammatory resolution, and increases phagocytosis by macrophages; selectively reduces the eicosanoids PGD2, PGE2, PGF2α, and TXB2 in the inflammatory exudate in a mouse model of peritonitis

Pricing & Availability

5,413

Cayman Chemical Picamilon, Purity: ≥98%, CAS: 34562-97-5, 500 mg

A GABA derivative; increases parietal cortical blood flow in rats and rabbits at 50 mg/kg, i.p. and 10 mg/kg, i.v., respectively; increases latency to enter the dark compartment in the passive avoidance conditioned reflex test in rats at 10 mg/kg compared with control animals

Pricing & Availability

5,414

Medchemexpress LLC Diloxanide furoate | 3736-81-0 | 99.6% | 25 MG

Diloxanide furoate is the proagent of Diloxanide. It is a potent and orally active anti-protozoal agent that can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.

Potent and orally active anti-protozoal agent.
Can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.
Potent activity against different strains of *E. histolytica* with MIC values ranging from 1.95 μg/ml to 2.5 μg/ml.
Effective against intestinal (caecal) amoebiasis in rats, with an ED50 value of 77.9 mg/kg.

Pricing & Availability

5,415

Cayman Chemical TP-0903, Purity: ≥98%, CAS: 1341200-45-0, 5 mg

An inhibitor of Axl (IC50 = 27 nM ); exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively; decreases the phosphorylation of Akt and Axl in GAS6-stimulated, serum-starved PSN-1 pancreatic cancer cells (EC50s = 305 and 222 nM, respectively); decreases cell viability (IC50 = 6 nM) and induces cell cycle arrest at the G2/M phase in PSN-1 cells at 30 nM; reduces the viability of CRC cell lines (IC50s = 4.5-123 nM); exhibits 69 and 44% tumor growth inhibition in an HCT116 mouse xenograft model and a K-Ras-mutant CRC PDX mouse model, respectively, at 40 mg/kg

Pricing & Availability

Bioactive Small Molecules

Filtered Search Results

Narrow Results

Medchemexpress LLC Brd0539 | 1403838-79-8 | MFCD32709969 | 98.3% | 452.54 | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Diloxanide furoate | 3736-81-0 | 99.6% | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Brd0539 | 1403838-79-8 | MFCD32709969 | 98.3% | 452.54 | 50 MG

Medchemexpress LLC Diloxanide furoate | 3736-81-0 | 99.6% | 25 MG